Reaction Details |
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Target | Acyl-protein thioesterase 1 [I75L,S82A,Q83P] |
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Ligand | BDBM207992 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Steady-State Kinetic Assays |
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pH | 6.5±n/a |
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Ki | 1200±70 nM |
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Comments | extracted |
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Citation | Won, SJ; Davda, D; Labby, KJ; Hwang, SY; Pricer, R; Majmudar, JD; Armacost, KA; Rodriguez, LA; Rodriguez, CL; Chong, FS; Torossian, KA; Palakurthi, J; Hur, ES; Meagher, JL; Brooks, CL; Stuckey, JA; Martin, BR Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol11:3374-3382 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acyl-protein thioesterase 1 [I75L,S82A,Q83P] |
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Name: | Acyl-protein thioesterase 1 [I75L,S82A,Q83P] |
Synonyms: | APT1 | Acyl-protein thioesterase 1 (APT1 I75L/S82A/Q83P) | LPL1 | LYPA1_HUMAN | LYPLA1 |
Type: | Protein |
Mol. Mass.: | 24623.32 |
Organism: | Homo sapiens (Human) |
Description: | Human APT1 with I75L/S82A/Q83P mutations |
Residue: | 230 |
Sequence: | MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRP
VTLNMNVAMPSWFDLIGLSPDAPEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQ
GGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLM
FGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID
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BDBM207992 |
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n/a |
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Name | BDBM207992 |
Synonyms: | ML349 |
Type | Small organic molecule |
Emp. Form. | C23H22N2O4S2 |
Mol. Mass. | 454.562 |
SMILES | COc1ccc(cc1)N1CCN(CC1)C(=O)c1cc2CS(=O)(=O)c3ccccc3-c2s1 |
Structure |
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