| Reaction Details |
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 | Report a problem with these data |
| Target | Insulin-degrading enzyme |
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| Ligand | BDBM209045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IDE Activity Assay |
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| IC50 | 90±n/a nM |
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| Citation |  Liu, DR; Maianti, JP; Saghatelian, A; Kleiner, RE Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof US Patent US9243038 Publication Date 1/26/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Insulin-degrading enzyme |
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| Name: | Insulin-degrading enzyme |
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| Synonyms: | 3.4.24.56 | IDE_MOUSE | Ide | Insulin degrading enzyme (mIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | Mouse Insulin Degrading Enzyme (mIDE) |
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| Type: | n/a |
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| Mol. Mass.: | 117770.69 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9JHR7 |
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| Residue: | 1019 |
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| Sequence: | MRNGLVWLLHPALPGTLRSILGARPPPAKRLCGFPKQTYSTMSNPAIQRIEDQIVKSPED
KREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKK
YPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLLDASCKD
REVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREE
LLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLRQ
LYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGYYLGHLIGHEGPGSLLSELKSKGWVNTLV
GGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAV
AFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAI
VSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILSL
EKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELL
KDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKRYNDKQPILLKKITEKMATFEIDKKRFE
IIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLL
SRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQ
QRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRA
NGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKL
SAECAKYWGEIISQQYNYDRDNIEVAYLKTLTKDDIIRFYQEMLAVDAPRRHKVSVHVLA
REMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL
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| BDBM209045 |
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| n/a |
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| Name | BDBM209045 |
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| Synonyms: | US9243038, 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H55N7O7 |
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| Mol. Mass. | 757.9181 |
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| SMILES | NCCCC[C@@H]1NC(=O)\C=C\C(=O)NC(CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC1=O)C(N)=O |r,t:9| |
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| Structure | 
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