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TargetBromodomain-containing protein 4 [44-168]/Histone H4
LigandBDBM209499
Substrate/Competitorn/a
Meas. Tech.AlphaScreen Assay
IC50 18±n/a nM
Citation Engelhardt, HGianni, DSmethurst, C Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors US Patent US9266891 Publication Date 2/23/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 [44-168]/Histone H4
Name:Bromodomain-containing protein 4 [44-168]/Histone H4
Synonyms:BRD4-BD1 and Histone H4
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Bromodomain-containing protein 4 [44-168]
Synonyms:BET bromodomain 4(1) (BRD4(1)) | BRD4 | BRD4-BD1 protein (aa 44-168) | BRD4_HUMAN | Bromodomain protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 (BRD4) (aa 44-168) | Bromodomain-containing protein 4 (BRD4-BD1) | Bromodomain-containing protein 4 bromodomain 1 (BRD4-BD1) | HUNK1
Type:Enzyme Catalytic Domain
Mol. Mass.:14866.49
Organism:Homo sapiens (Human)
Description:aa (44-168)
Residue:125
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
LPTEE
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Component 2
Name:Histone H4
Synonyms:H4-16 | H4/A | H4/B | H4/C | H4/D | H4/E | H4/G | H4/H | H4/I | H4/J | H4/K | H4/M | H4/N | H4/O | H4C1 | H4F2 | H4FA | H4FB | H4FC | H4FD | H4FE | H4FG | H4FH | H4FI | H4FJ | H4FK | H4FM | H4FN | H4FO | H4_HUMAN | HIST1H4A | HIST1H4B | HIST1H4C | HIST1H4D | HIST1H4E | HIST1H4F | HIST1H4H | HIST1H4I | HIST1H4J | HIST1H4K | HIST1H4L | HIST2H4 | HIST2H4A | HIST2H4B | HIST4H4 | and | andH4/B | andH4/C | andH4/D | andH4/E | andH4/G | andH4/H | andH4/I | andH4/J | andH4/K | andH4/M | andH4/N | andH4/O
Type:Protein
Mol. Mass.:11386.36
Organism:Homo sapiens (Human)
Description:P62805
Residue:103
Sequence:
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK
VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
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BDBM209499
n/a
NameBDBM209499
Synonyms:US10328074, Example III-40 | US11077107, Example III-40 | US9266891, III-40
TypeSmall organic molecule
Emp. Form.C24H27N9
Mol. Mass.441.5315
SMILESCC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)C(C)C
Structure
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