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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM209552 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM209552 | |||
| n/a | |||
| Name | BDBM209552 | ||
| Synonyms: | US9271969, 40 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H24F3N3O3 | ||
| Mol. Mass. | 507.5037 | ||
| SMILES | OC(=O)C[C@H]1CCC(CC1)c1ccc(cc1)-c1ccc2nc(cn2c1)C(=O)Nc1cc(F)c(F)c(F)c1 |r,wD:4.3,(12.75,-5.08,;11.42,-4.31,;11.42,-2.77,;10.09,-5.08,;8.75,-4.31,;8.75,-2.77,;7.42,-2,;6.09,-2.77,;6.09,-4.31,;7.42,-5.08,;4.75,-2,;3.42,-2.77,;2.09,-2,;2.09,-.46,;3.42,.31,;4.75,-.46,;.75,.31,;.75,1.85,;-.58,2.62,;-1.92,1.85,;-3.38,2.33,;-4.29,1.08,;-3.38,-.17,;-1.92,.31,;-.58,-.46,;-5.83,1.08,;-6.59,-.25,;-6.59,2.41,;-8.14,2.41,;-8.91,3.75,;-10.45,3.75,;-11.22,5.08,;-11.22,2.41,;-12.75,2.41,;-10.45,1.08,;-11.22,-.25,;-8.91,1.08,)| | ||
| Structure | 
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