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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM209530 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | <1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Kim, D; Bok, J; Shin, S Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme US Patent US9271969 Publication Date 3/1/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM209530 | |||
| n/a | |||
| Name | BDBM209530 | ||
| Synonyms: | US9271969, 18 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H30F3N3O5 | ||
| Mol. Mass. | 581.5822 | ||
| SMILES | COc1ccc(OC(F)(F)F)cc1CNC(=O)c1cn2cc(ccc2n1)-c1ccc(cc1)C1CC[C@H](CC(O)=O)CC1 |r,wD:35.39,(-5.83,5.49,;-6.6,4.16,;-8.14,4.16,;-8.91,5.49,;-10.45,5.49,;-11.22,4.16,;-12.76,4.16,;-13.84,3.07,;-14.93,1.98,;-12.76,1.98,;-14.61,4.41,;-10.45,2.83,;-8.91,2.83,;-8.14,1.49,;-6.6,1.49,;-5.83,.16,;-6.6,-1.17,;-4.29,.16,;-3.38,-1.09,;-1.92,-.61,;-.58,-1.38,;.75,-.61,;.75,.93,;-.58,1.7,;-1.92,.93,;-3.38,1.41,;2.09,-1.38,;2.09,-2.92,;3.42,-3.69,;4.75,-2.92,;4.75,-1.38,;3.42,-.61,;6.09,-3.69,;7.42,-2.92,;8.75,-3.69,;8.75,-5.23,;10.09,-6,;11.42,-5.23,;12.76,-6,;11.42,-3.69,;7.42,-6,;6.09,-5.23,)| | ||
| Structure | 
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