| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 2 [596-900] |
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| Ligand | BDBM50363397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinobeads Competition Assay |
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| Kd | 869±0.0 nM |
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| Citation |  Heinzlmeir, S; Kudlinzki, D; Sreeramulu, S; Klaeger, S; Gande, SL; Linhard, V; Wilhelm, M; Qiao, H; Helm, D; Ruprecht, B; Saxena, K; Médard, G; Schwalbe, H; Kuster, B Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol11:3400-3411 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-A receptor 2 [596-900] |
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| Name: | Ephrin type-A receptor 2 [596-900] |
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| Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin type-A receptor 2 (EPHA2) |
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| Type: | Protein |
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| Mol. Mass.: | 34367.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EPHA2 truncation (596-900 aa); 519U |
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| Residue: | 305 |
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| Sequence: | DPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK
QRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQ
LVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS
GGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR
LPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRL
PSTSG
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| BDBM50363397 |
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| n/a |
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| Name | BDBM50363397 |
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| Synonyms: | CHEMBL1946170 | REGORAFENIB | US10183928, Regorafenib | US10202365, Compound Regorafenib | US10227329, Compound Regorafenib | US10464902, Regorafenib | US10584114, Compound Regorafenib | US10774070, Compound Regorafenib | US11279688, Compound Regorafenib |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15ClF4N4O3 |
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| Mol. Mass. | 482.815 |
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| SMILES | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1 |
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| Structure | 
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