Reaction Details |
| Report a problem with these data |
Target | Ephrin type-A receptor 2 [596-900] |
---|
Ligand | BDBM209860 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | HotSpot Kinase Activity Assay |
---|
IC50 | 17±0.0 nM |
---|
Citation | Heinzlmeir, S; Kudlinzki, D; Sreeramulu, S; Klaeger, S; Gande, SL; Linhard, V; Wilhelm, M; Qiao, H; Helm, D; Ruprecht, B; Saxena, K; Médard, G; Schwalbe, H; Kuster, B Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol11:3400-3411 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ephrin type-A receptor 2 [596-900] |
---|
Name: | Ephrin type-A receptor 2 [596-900] |
Synonyms: | ECK | EPHA2 | EPHA2_HUMAN | Ephrin type-A receptor 2 (EPHA2) |
Type: | Protein |
Mol. Mass.: | 34367.96 |
Organism: | Homo sapiens (Human) |
Description: | EPHA2 truncation (596-900 aa); 519U |
Residue: | 305 |
Sequence: | DPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK
QRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQ
LVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS
GGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR
LPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRL
PSTSG
|
|
|
BDBM209860 |
---|
n/a |
---|
Name | BDBM209860 |
Synonyms: | 4-[[(3S)-3-(dimethylamino)pyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(5-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | Bafetinib |
Type | Small organic molecule |
Emp. Form. | C30H31F3N8O |
Mol. Mass. | 576.6153 |
SMILES | CN(C)[C@H]1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(Nc3ncc(cn3)-c3cncnc3)c2)C1 |
Structure |
|