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TargetTyrosine-protein kinase Blk
LigandBDBM209866
Substrate/Competitorn/a
Meas. Tech.JAK Enzyme Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 19900±0 nM
Commentsextracted
Citation Telliez JBDowty MEWang LJussif JLin TLi LMoy EBalbo PLi WZhao YCrouse KDickinson CSymanowicz PHegen MBanker MEVincent FUnwalla RLiang SGilbert AMBrown MFHayward MMontgomery JYang XBauman JTrujillo JICasimiro-Garcia AVajdos FFLeung LGeoghegan KFQuazi AXuan DJones LHett EWright KClark JDThorarensen A Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol 11:3442-3451 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Blk
Name:SRC
Synonyms:B lymphoid tyrosine kinase | BLK | Tyrosine-protein kinase BLK (BLK) | p55-Blk
Type:Protein
Mol. Mass.:57711.88
Organism:Homo sapiens (Human)
Description:n/a
Residue:505
Sequence:
MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
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  Blast E-value cutoff:
BDBM209866
n/a
NameBDBM209866
Synonyms:PF-06651600 | US9617258, Example 5
TypeSmall organic molecule
Emp. Form.C15H19N5O
Mol. Mass.285.3443
SMILESC[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r|
Structure
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