| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Ligand | BDBM209866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | JAK Enzyme Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >50000±0 nM |
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| Comments | extracted |
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| Citation |  Telliez, JB; Dowty, ME; Wang, L; Jussif, J; Lin, T; Li, L; Moy, E; Balbo, P; Li, W; Zhao, Y; Crouse, K; Dickinson, C; Symanowicz, P; Hegen, M; Banker, ME; Vincent, F; Unwalla, R; Liang, S; Gilbert, AM; Brown, MF; Hayward, M; Montgomery, J; Yang, X; Bauman, J; Trujillo, JI; Casimiro-Garcia, A; Vajdos, FF; Leung, L; Geoghegan, KF; Quazi, A; Xuan, D; Jones, L; Hett, E; Wright, K; Clark, JD; Thorarensen, A Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol11:3442-3451 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 7 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4 |
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| Type: | Protein |
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| Mol. Mass.: | 47502.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14733 |
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| Residue: | 419 |
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| Sequence: | MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
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| BDBM209866 |
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| n/a |
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| Name | BDBM209866 |
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| Synonyms: | PF-06651600 | US11111242, Example 5 | US20230348487, Example PF-06651600 | US9617258, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N5O |
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| Mol. Mass. | 285.3443 |
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| SMILES | C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r| |
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| Structure | 
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