| Reaction Details |
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 | Report a problem with these data |
| Target | GDH/6PGL endoplasmic bifunctional protein |
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| Ligand | BDBM50446130 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | H6PD Activity Assay |
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| IC50 | 1.8e+4±n/a nM |
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| Citation |  Knezevic, CE; Wright, G; Remsing Rix, LL; Kim, W; Kuenzi, BM; Luo, Y; Watters, JM; Koomen, JM; Haura, EB; Monteiro, AN; Radu, C; Lawrence, HR; Rix, U Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets. Cell Chem Biol23:1490-1503 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| GDH/6PGL endoplasmic bifunctional protein |
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| Name: | GDH/6PGL endoplasmic bifunctional protein |
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| Synonyms: | G6PE_HUMAN | GDH | H6PD | Hexose-6-phosphate dehydrogenase (H6PD) |
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| Type: | Protein |
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| Mol. Mass.: | 88905.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O95479 |
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| Residue: | 791 |
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| Sequence: | MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSF
SFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQAL
NKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDH
FSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEII
MKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQAL
RGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGK
ALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFR
PSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLL
ASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMP
SDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQ
QLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQ
RLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTT
SPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQL
VWYMDYDAFLG
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| BDBM50446130 |
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| n/a |
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| Name | BDBM50446130 |
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| Synonyms: | AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucaparib |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18FN3O |
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| Mol. Mass. | 323.3641 |
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| SMILES | CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23 |
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| Structure | 
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