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TargetAurora kinase A
LigandBDBM92817
Substrate/Competitorn/a
Meas. Tech.In Vitro Aurora A Activity Assay (DiscoverX)
pH7.4±n/a
Temperature298.15±n/a K
IC50 3.3±1.5 nM
Commentsextracted
Citation Sebti SMSchönbrunn ELawrence NJLawrence HRMartin MP Aurora kinase inhibitors and methods of making and using thereof US Patent  US9249124 Publication Date 2/2/2016
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:ARK1 | AURKA | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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  Blast E-value cutoff:
BDBM92817
n/a
NameBDBM92817
Synonyms:Bisanilinopyrimidine, 6j | US9249124, 33
TypeSmall molecule
Emp. Form.C18H15ClN4O2
Mol. Mass.354.79
SMILESOC(=O)Cc1ccc(Nc2nccc(Nc3ccccc3Cl)n2)cc1
Structure
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