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TargetAurora kinase A
LigandBDBM92843
Substrate/Competitorn/a
Meas. Tech.Protein Crystallography Inhibitory Activity Assay
pH7.4±n/a
Temperature291.15±n/a K
IC50 3.1±0.4 nM
Commentsextracted
Citation Sebti, SMSchönbrunn, ELawrence, NJLawrence, HRMartin, MP Aurora kinase inhibitors and methods of making and using thereof US Patent US9249124 Publication Date 2/2/2016
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase A
Name:Aurora kinase A
Synonyms:AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1
Type:Serine/threonine-protein kinase
Mol. Mass.:45830.98
Organism:Homo sapiens (Human)
Description:O14965
Residue:403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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  Blast E-value cutoff:
BDBM92843
n/a
NameBDBM92843
Synonyms:Bisanilinopyrimidine, 12a | US9249124, 59
TypeSmall molecule
Emp. Form.C17H13ClN8
Mol. Mass.364.792
SMILESClc1ccccc1Nc1ccnc(Nc2ccc(cc2)-c2nnn[nH]2)n1
Structure
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