| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A] |
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| Ligand | BDBM210938 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CA Inhibition Assay |
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| Ki | 0.2±0.0 nM |
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| Citation |  Bhatt, A; Mahon, BP; Cruzeiro, VW; Cornelio, B; Laronze-Cochard, M; Ceruso, M; Sapi, J; Rance, GA; Khlobystov, AN; Fontana, A; Roitberg, A; Supuran, CT; McKenna, R Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity. Chembiochem18:213-222 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A] |
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| Name: | Carbonic anhydrase 2 [A65S,N67Q,E69T,I91L,F131V,K170E,L204A] |
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| Synonyms: | CA2 | CAH2_HUMAN | Carbonic anhydrase 9 (CA IX) |
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| Type: | Protein |
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| Mol. Mass.: | 29162.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Chimeric protein of CA II with 7 mutations (A65S, N67Q, E69T, I91L, F131V, K170E, L204A); 5sZ4, 5SZ5, 5SZ6, 5SZ7 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHSFQVTFDDSQDKAVLKGGPLDGTYRLLQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDVGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLAECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM210938 |
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| n/a |
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| Name | BDBM210938 |
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| Synonyms: | 4-(3-quinolinyl)-benzenesulfonamide (4p) |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N2O2S |
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| Mol. Mass. | 284.333 |
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| SMILES | NS(=O)(=O)c1ccc(cc1)-c1cnc2ccccc2c1 |
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| Structure | 
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