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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Heat shock protein HSP 90-alpha | ||
| Ligand | BDBM210950 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Polarization (FP) Assay | ||
| pH | 7.3±n/a | ||
| Kd | >1.00e+5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Mishra, SJ; Ghosh, S; Stothert, AR; Dickey, CA; Blagg, BS Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold. ACS Chem Biol12:244-253 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Heat shock protein HSP 90-alpha | |||
| Name: | Heat shock protein HSP 90-alpha | ||
| Synonyms: | HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 | ||
| Type: | Molecular Chaperone | ||
| Mol. Mass.: | 84623.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07900 | ||
| Residue: | 732 | ||
| Sequence: |
| ||
| BDBM210950 | |||
| n/a | |||
| Name | BDBM210950 | ||
| Synonyms: | 2-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(2-phenethyl-1H-pyrrol-1-yl)benzamide (9) | US10975030, Compound 9 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H29N3O2 | ||
| Mol. Mass. | 403.5167 | ||
| SMILES | NC(=O)c1ccc(cc1NC1CCC(O)CC1)-n1cccc1CCc1ccccc1 |(9.14,6.59,;7.8,5.82,;6.47,6.59,;7.8,4.28,;6.47,3.51,;6.47,1.97,;7.8,1.2,;9.14,1.97,;9.14,3.51,;10.47,4.28,;11.8,3.51,;13.14,4.28,;14.47,3.51,;14.47,1.97,;15.8,1.2,;13.14,1.2,;11.8,1.97,;7.8,-.34,;6.56,-1.25,;7.03,-2.71,;8.57,-2.71,;9.05,-1.25,;10.51,-.77,;11.66,-1.8,;13.12,-1.33,;13.44,.18,;14.91,.65,;16.05,-.38,;15.73,-1.88,;14.27,-2.36,)| | ||
| Structure | 
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