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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Heat shock protein HSP 90-alpha | ||
| Ligand | BDBM210959 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Polarization (FP) Assay | ||
| pH | 7.3±n/a | ||
| Kd | >1.00e+5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Mishra, SJ; Ghosh, S; Stothert, AR; Dickey, CA; Blagg, BS Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold. ACS Chem Biol12:244-253 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Heat shock protein HSP 90-alpha | |||
| Name: | Heat shock protein HSP 90-alpha | ||
| Synonyms: | HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 | ||
| Type: | Molecular Chaperone | ||
| Mol. Mass.: | 84623.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07900 | ||
| Residue: | 732 | ||
| Sequence: |
| ||
| BDBM210959 | |||
| n/a | |||
| Name | BDBM210959 | ||
| Synonyms: | 4-(2-(2-hydroxybenzyl)-1H-pyrrol-1-yl)-2-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide (8j) | US10975030, Compound 8j | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27N3O3 | ||
| Mol. Mass. | 405.4895 | ||
| SMILES | NC(=O)c1ccc(cc1NC1CCC(O)CC1)-n1cccc1Cc1ccccc1O |(2.47,4.51,;3.8,3.74,;5.14,4.51,;3.8,2.2,;2.47,1.43,;2.47,-.11,;3.8,-.88,;5.14,-.11,;5.14,1.43,;6.47,2.2,;7.8,1.43,;9.14,2.2,;10.47,1.43,;10.47,-.11,;11.8,-.88,;9.14,-.88,;7.8,-.11,;3.8,-2.42,;2.56,-3.33,;3.03,-4.79,;4.57,-4.79,;5.05,-3.33,;6.51,-2.85,;7.66,-3.88,;7.34,-5.39,;8.48,-6.42,;9.95,-5.95,;10.27,-4.44,;9.12,-3.41,;9.44,-1.9,)| | ||
| Structure | 
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