Reaction Details |
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Target | Bifunctional cytochrome P450/NADPH--P450 reductase [A82F,F87V] |
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Ligand | BDBM50241343 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Optical Titration Assay |
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pH | 7±n/a |
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Kd | 212± 14 nM |
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Comments | extracted |
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Citation | Butler, CF; Peet, C; Mason, AE; Voice, MW; Leys, D; Munro, AW Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias. J Biol Chem288:25387-99 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional cytochrome P450/NADPH--P450 reductase [A82F,F87V] |
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Name: | Bifunctional cytochrome P450/NADPH--P450 reductase [A82F,F87V] |
Synonyms: | CPXB_PRIM2 | Cytochrome P450 monooxygenase BM3 (BM3 DM) | cyp102 | cyp102A1 |
Type: | Protein |
Mol. Mass.: | 117780.88 |
Organism: | Bacillus megaterium |
Description: | B. megaterium BM3 with A82F/F87V mutations |
Residue: | 1049 |
Sequence: | MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIK
EACDESRFDKNLSQALKFVRDFFGDGLVTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMM
VDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVR
ALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLN
GKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLV
DPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQ
LHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLK
HFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHN
TPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGH
PPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIAD
RGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMH
GAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFG
LDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVE
LEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDE
KQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLI
MVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIIT
LHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYAD
VHQVSEADARLWLQQLEEKGRYAKDVWAG
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BDBM50241343 |
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n/a |
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Name | BDBM50241343 |
Synonyms: | (RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1H-benzo[d]imidazole | (omeprazole)5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole | 2-(3-methoxy-2,4-dimethylbenzylsulfinyl)-6-methoxy-1H-benzo[d]imidazole | 5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole | 5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole (omeprazole) | 5-Methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole(omeprazole) | 5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole | 5-methoxy-2-(2-(4-methoxy-3,5-dimethylpyridin-2-yl)ethylsulfinyl)-1H-benzo[d]imidazole | 6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole | CHEMBL1503 | ESOMEPRAZOLE SODIUM | H-168/68 | OMEPRAZOLE | Omeprazole (OMP) | Prilosec | cid_4594 |
Type | Small organic molecule |
Emp. Form. | C17H19N3O3S |
Mol. Mass. | 345.416 |
SMILES | COc1ccc2nc([nH]c2c1)S(=O)Cc1ncc(C)c(OC)c1C |
Structure |
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