Reaction Details | |||
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Target | Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 | ||
Ligand | BDBM213144 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
IC50 | 5±n/a nM | ||
Citation | Bungard, CJ; Converso, A; Hanney, B; Hartingh, TJ; Manley, PJ; Meissner, RS; Perkins, JJ; Rudd, MT Quinoline carboxamide and quinoline carbonitrile derivatives as mGluR2-negative allosteric modulators, compositions, and their use US Patent US9278960 Publication Date 3/8/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 | |||
Name: | Guanine nucleotide-binding protein subunit alpha-15 [Y147C]/Metabotropic glutamate receptor 2 | ||
Synonyms: | mGluR2 and G alpha 16 | ||
Type: | Protein | ||
Mol. Mass.: | n/a | ||
Description: | n/a | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Metabotropic glutamate receptor 2 | ||
Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 95584.88 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14416 | ||
Residue: | 872 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Guanine nucleotide-binding protein subunit alpha-15 [Y147C] | ||
Synonyms: | G protein alpha 16 | GNA15 | GNA15_HUMAN | GNA16 | ||
Type: | Enzyme | ||
Mol. Mass.: | 43517.59 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P30679[Y147C] | ||
Residue: | 374 | ||
Sequence: |
| ||
BDBM213144 | |||
n/a | |||
Name | BDBM213144 | ||
Synonyms: | US9278960, 8-51 | US9636337, 8-51 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H20F2N4O2 | ||
Mol. Mass. | 434.438 | ||
SMILES | COc1cc(F)c(c(F)c1)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O |(5.33,-6.16,;4,-5.39,;4,-3.85,;5.33,-3.08,;5.33,-1.54,;6.67,-.77,;4,-.77,;2.67,-1.54,;1.33,-.77,;2.67,-3.08,;4,.77,;5.33,1.54,;5.33,3.08,;4,3.85,;2.67,3.08,;1.33,3.85,;,3.08,;-1.33,3.85,;-2.67,3.08,;-4,3.85,;-4,5.39,;-5.33,6.16,;-6.67,5.39,;-8,6.16,;-6.67,3.85,;-5.33,3.08,;,1.54,;1.33,.77,;2.67,1.54,;6.67,3.85,;8,3.08,;6.67,5.39,)| | ||
Structure |