Reaction Details |
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Target | Prostaglandin G/H synthase 2 |
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Ligand | BDBM209868 |
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Substrate/Competitor | n/a |
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Meas. Tech. | POX Assay |
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pH | 8±n/a |
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Kd | 1.6e+2± 5e+1 nM |
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Comments | extracted |
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Citation | Dong, L; Sharma, NP; Jurban, BJ; Smith, WL Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer. J Biol Chem288:28641-55 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 2 |
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Name: | Prostaglandin G/H synthase 2 |
Synonyms: | His8-Native/FLAG-Native |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Prostaglandin G/H synthase 2 |
Synonyms: | COX2 | Cyclooxygenase-2 (COX-2) | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (PGHS-2)(His8-Native) |
Type: | Enzyme |
Mol. Mass.: | 70105.04 |
Organism: | Homo sapiens (Human) |
Description: | P35354; containing an octahistidine (His8) tag at the N terminus |
Residue: | 612 |
Sequence: | HHHHHHHHMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGE
NCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDS
PPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRK
FIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRL
FKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWL
REHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELL
FNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESF
TRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKE
MSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWK
PSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL
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Component 2 |
Name: | Prostaglandin G/H synthase 2 |
Synonyms: | COX2 | Cyclooxygenase-2 (COX-2) | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (PGHS-2)(FLAG-Native) |
Type: | Enzyme |
Mol. Mass.: | 69995.82 |
Organism: | Homo sapiens (Human) |
Description: | P35354; containing a FLAG tag at the N terminus |
Residue: | 612 |
Sequence: | DYKDDDDKMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGE
NCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDS
PPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRK
FIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRL
FKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWL
REHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELL
FNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESF
TRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKE
MSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWK
PSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL
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BDBM209868 |
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n/a |
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Name | BDBM209868 |
Synonyms: | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+) | Haemin | Heme |
Type | Small organic molecule |
Emp. Form. | C34H32N4O4 |
Mol. Mass. | 560.6434 |
SMILES | Cc1c(C=C)c2cc3[n-]c(cc4[n-]c(cc5nc(cc1n2)c(C=C)c5C)c(C)c4CCC(O)=O)c(CCC(O)=O)c3C |
Structure |
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