| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dimer of Prostaglandin G/H synthase 2 [Y385F] |
|---|
| Ligand | BDBM209868 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | POX Assay |
|---|
| pH | 8±n/a |
|---|
| Kd | 1.6e+3± 2e+2 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Dong, L; Sharma, NP; Jurban, BJ; Smith, WL Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer. J Biol Chem288:28641-55 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dimer of Prostaglandin G/H synthase 2 [Y385F] |
|---|
| Name: | Dimer of Prostaglandin G/H synthase 2 [Y385F] |
|---|
| Synonyms: | His8-Y385F/His8-Y385F |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Prostaglandin G/H synthase 2 [Y385F] |
|---|
| Synonyms: | COX2 | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (His8-Y385F) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70089.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human PGHS-2 Y385F mutant with an octahistidine tag at the N terminus |
|---|
| Residue: | 612 |
|---|
| Sequence: | HHHHHHHHMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGE
NCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDS
PPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRK
FIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRL
FKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWL
REHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELL
FNKQFQYQNRIAAEFNTLFHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESF
TRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKE
MSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWK
PSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL
|
|
|
|---|
| Component 2 |
| Name: | Prostaglandin G/H synthase 2 [Y385F] |
|---|
| Synonyms: | COX2 | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (His8-Y385F) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 70089.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human PGHS-2 Y385F mutant with an octahistidine tag at the N terminus |
|---|
| Residue: | 612 |
|---|
| Sequence: | HHHHHHHHMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGE
NCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDS
PPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRK
FIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRL
FKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWL
REHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELL
FNKQFQYQNRIAAEFNTLFHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESF
TRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKE
MSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWK
PSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDIN
PTVLLKERSTEL
|
|
|
|---|
| BDBM209868 |
|---|
| n/a |
|---|
| Name | BDBM209868 |
|---|
| Synonyms: | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+) | Haemin | Heme |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H32N4O4 |
|---|
| Mol. Mass. | 560.6434 |
|---|
| SMILES | Cc1c(C=C)c2cc3[n-]c(cc4[n-]c(cc5nc(cc1n2)c(C=C)c5C)c(C)c4CCC(O)=O)c(CCC(O)=O)c3C |
|---|
| Structure | 
|
|---|
Search and Browse
