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TargetInterlukin-2-inducible tyrosine kinase (Itk)
LigandBDBM213220
Substrate/Competitorn/a
Meas. Tech.LanthaScreen Kinase Binding Assay
IC50 5.0±0 nM
Citation Harling JDDeakin AMCampos SGrimley RChaudry LNye CPolyakova OBessant CMBarton NSomers DBarrett JGraves RHHanns LKerr WJSolari R Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. J Biol Chem 288:28195-206 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interlukin-2-inducible tyrosine kinase (Itk)
Name:Interlukin-2-inducible tyrosine kinase (Itk)
Synonyms:n/a
Type:Enzyme
Mol. Mass.:30027.99
Organism:Homo sapiens (Human)
Description:Human Itk truncation (357-620 aa) with Y512E mutation
Residue:264
Sequence:
VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHP
KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEA
CVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQETSSTGTKFPVKWASPEVFSFSRYS
SKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWK
ERPEDRPAFSRLLRQLAEIAESGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM213220
n/a
NameBDBM213220
Synonyms:N-[(3S)-1-Acryloyl-3-pyrrolidinyl]-4-{[cis-2,6-dimethyl-4-morpholinyl]methyl}-N'-[1,3]thiazolo[5,4-b]pyridin-2-yl-2,6-pyridinediamine (9)
TypeSmall organic molecule
Emp. Form.C25H31N7O2S
Mol. Mass.493.624
SMILESC[C@H]1CN(Cc2cc(N[C@H]3CCN(C3)C(=O)C=C)nc(Nc3nc4cccnc4s3)c2)C[C@@H](C)O1 |r|
Structure
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