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TargetInterlukin-2-inducible tyrosine kinase (Itk)
LigandBDBM213222
Substrate/Competitorn/a
Meas. Tech.LanthaScreen Kinase Binding Assay
IC50 32±0 nM
Citation Harling JDDeakin AMCampos SGrimley RChaudry LNye CPolyakova OBessant CMBarton NSomers DBarrett JGraves RHHanns LKerr WJSolari R Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. J Biol Chem 288:28195-206 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Interlukin-2-inducible tyrosine kinase (Itk)
Name:Interlukin-2-inducible tyrosine kinase (Itk)
Synonyms:n/a
Type:Enzyme
Mol. Mass.:30027.99
Organism:Homo sapiens (Human)
Description:Human Itk truncation (357-620 aa) with Y512E mutation
Residue:264
Sequence:
VIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHP
KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEA
CVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQETSSTGTKFPVKWASPEVFSFSRYS
SKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWK
ERPEDRPAFSRLLRQLAEIAESGL
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  Blast E-value cutoff:
BDBM213222
n/a
NameBDBM213222
Synonyms:(S)-1-(3-((4-((Dimethylamino)methyl)-6-(thiazolo[5,4-b]pyridin-2-ylamino)pyridin-2-yl)amino)pyrrolidin-1-yl)prop-2-en-1-one (11)
TypeSmall organic molecule
Emp. Form.C21H25N7OS
Mol. Mass.423.535
SMILESCN(C)Cc1cc(N[C@H]2CCN(C2)C(=O)C=C)nc(Nc2nc3cccnc3s2)c1 |r|
Structure
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