| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 2 |
|---|
| Ligand | BDBM50112347 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Z'-LYTEBiochemical Assay |
|---|
| IC50 | 12.8±0.0 nM |
|---|
| Citation |  Licciulli, S; Maksimoska, J; Zhou, C; Troutman, S; Kota, S; Liu, Q; Duron, S; Campbell, D; Chernoff, J; Field, J; Marmorstein, R; Kissil, JL FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas. J Biol Chem288:29105-14 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PAK 2 |
|---|
| Name: | Serine/threonine-protein kinase PAK 2 |
|---|
| Synonyms: | PAK2 | PAK2_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | Serine/threonine-protein kinase PAK 2 | Serine/threonine-protein kinase PAK 2 (PAK2) | p21-Activated kinase 2 (PAK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 58037.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13177 |
|---|
| Residue: | 524 |
|---|
| Sequence: | MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGT
EKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNP
QAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAP
PVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIV
SIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKE
LKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLH
ANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY
GPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRC
LEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR
|
|
|
|---|
| BDBM50112347 |
|---|
| n/a |
|---|
| Name | BDBM50112347 |
|---|
| Synonyms: | CHEMBL3609327 | FRAX597 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H28ClN7OS |
|---|
| Mol. Mass. | 558.097 |
|---|
| SMILES | CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
