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TargetTyrosine-protein kinase ABL1 [64-515]
LigandBDBM213677
Substrate/Competitorn/a
Meas. Tech.Caliper ABL
pH7.5±n/a
Temperature303.15±n/a K
IC50<0.13±n/a nM
Commentsextracted
Citation Furet, PGrotzfeld, RMJahnke, WJones, DBManley, PWMarzinzik, APelle, XFSalem, BSchoepfer, JSpieser, EA Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9278981 Publication Date 3/8/2016
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase ABL1 [64-515]
Name:Tyrosine-protein kinase ABL1 [64-515]
Synonyms:ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:Enzyme Catalytic Domain
Mol. Mass.:51539.77
Organism:Homo sapiens (Human)
Description:aa 64-515
Residue:452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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  Blast E-value cutoff:
BDBM213677
n/a
NameBDBM213677
Synonyms:US9278981, 269
TypeSmall organic molecule
Emp. Form.C23H18ClF2N5O4
Mol. Mass.501.87
SMILESO[C@H]1CN(C[C@@H]1O)c1ncc(cc1-c1cncc(c1)C#N)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r|
Structure
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