| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [64-515] |
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| Ligand | BDBM213699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Caliper ABL |
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| pH | 7.5±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 0.2±n/a nM |
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| Comments | extracted |
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| Citation |  Furet, P; Grotzfeld, RM; Jahnke, W; Jones, DB; Manley, PW; Marzinzik, A; Pelle, XF; Salem, B; Schoepfer, J; Spieser, EA Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9278981 Publication Date 3/8/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase ABL1 [64-515] |
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| Name: | Tyrosine-protein kinase ABL1 [64-515] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51539.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 64-515 |
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| Residue: | 452 |
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| Sequence: | NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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| BDBM213699 |
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| n/a |
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| Name | BDBM213699 |
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| Synonyms: | US9278981, 291 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21ClF2N4O3 |
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| Mol. Mass. | 474.888 |
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| SMILES | Cc1ccncc1-c1cc(cnc1N1CC[C@@H](O)C1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |r| |
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| Structure | 
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