| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Catenin beta-1 [138-686]/Transcription factor 4 [7-51] |
|---|
| Ligand | BDBM213761 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | AlphaScreen Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 3830±450 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent US9284299 Publication Date 3/15/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Catenin beta-1 [138-686]/Transcription factor 4 [7-51] |
|---|
| Name: | Catenin beta-1 [138-686]/Transcription factor 4 [7-51] |
|---|
| Synonyms: | Beta-catenin/Tcf4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Catenin beta-1 [138-686] |
|---|
| Synonyms: | Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 60127.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 138-686 |
|---|
| Residue: | 549 |
|---|
| Sequence: | NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSA
IVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAIT
TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILA
SGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRL
VQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMM
VCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKL
LHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ
QQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGV
LCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVE
LTSSLFRTE
|
|
|
|---|
| Component 2 |
| Name: | Transcription factor 4 [7-51] |
|---|
| Synonyms: | BHLHB19 | ITF2 | ITF2_HUMAN | SEF2 | TCF4 | Transcription factor 4 (TCF4) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 4569.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human Tcf4 truncation (7-51 aa) |
|---|
| Residue: | 45 |
|---|
| Sequence: | MAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVE
|
|
|
|---|
| BDBM213761 |
|---|
| n/a |
|---|
| Name | BDBM213761 |
|---|
| Synonyms: | US9284299, 12 | US9738628, Compound 12 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H9N7O |
|---|
| Mol. Mass. | 231.2141 |
|---|
| SMILES | On1nnc2cc(CCc3nn[nH]n3)ccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
