| Reaction Details |
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 | Report a problem with these data |
| Target | Cadherin-1 [819-873]/Catenin beta-1 [138-686] |
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| Ligand | BDBM213748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization (FP) Assay |
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| Temperature | 298.15±n/a K |
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| Ki | 13040±310 nM |
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| Comments | extracted |
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| Citation |  Ji, H; Yu, B; Zhang, M; Guo, W Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions US Patent US9284299 Publication Date 3/15/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cadherin-1 [819-873]/Catenin beta-1 [138-686] |
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| Name: | Cadherin-1 [819-873]/Catenin beta-1 [138-686] |
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| Synonyms: | Beta-catenin/E-cadherin |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Catenin beta-1 [138-686] |
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| Synonyms: | Beta-catenin | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | Protein |
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| Mol. Mass.: | 60127.24 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 138-686 |
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| Residue: | 549 |
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| Sequence: | NLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSA
IVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAIT
TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILA
SGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRL
VQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMM
VCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKL
LHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQ
QQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGV
LCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVE
LTSSLFRTE
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| Component 2 |
| Name: | Cadherin-1 [819-873] |
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| Synonyms: | CADH1_HUMAN | CDH1 | CDHE | Epithelial cadherin (E-cadherin) | UVO |
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| Type: | Enzyme |
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| Mol. Mass.: | 6102.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human E-cadherin truncation (819-873 aa) |
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| Residue: | 55 |
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| Sequence: | DTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLA
|
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| BDBM213748 |
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| n/a |
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| Name | BDBM213748 |
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| Synonyms: | US9284299, PKF115-584 | US9738628, Compound PKF115-584 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H38O14 |
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| Mol. Mass. | 790.7641 |
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| SMILES | COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(C[C@@H](C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(C[C@@H](C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O |r| |
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| Structure | 
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