Reaction Details |
| Report a problem with these data |
Target | Putative lanosterol 14-alpha-demethylase |
---|
Ligand | BDBM213823 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | CYP51 Inhibition Assay |
---|
pH | 7.4±n/a |
---|
Temperature | 310.15±n/a K |
---|
Kd | 156± 6 nM |
---|
Comments | extracted |
---|
Citation | Hargrove, TY; Wawrzak, Z; Alexander, PW; Chaplin, JH; Keenan, M; Charman, SA; Perez, CJ; Waterman, MR; Chatelain, E; Lepesheva, GI Complexes of Trypanosoma cruzi sterol 14a-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity. J Biol Chem288:31602-15 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Putative lanosterol 14-alpha-demethylase |
---|
Name: | Putative lanosterol 14-alpha-demethylase |
Synonyms: | Sterol 14α-demethylase (CYP51) |
Type: | Protein |
Mol. Mass.: | 54162.02 |
Organism: | Leishmania infantum |
Description: | A2TEF2 |
Residue: | 480 |
Sequence: | MIGELLLLLAAGLALYGWYFCKSFNTTRPTDPPVVHGTTPFVGHIIQFGKDPLGFMLKAK
KKYGGIFTMNICGNRITVVGDVHQHSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYP
RMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQ
CLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILS
EIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTT
WSLLHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMR
KVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAGVH
KCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIKKKKAAA
|
|
|
BDBM213823 |
---|
n/a |
---|
Name | BDBM213823 |
Synonyms: | EPL-BS1246 (UDO) |
Type | Small organic molecule |
Emp. Form. | C24H21ClF3N3O |
Mol. Mass. | 459.891 |
SMILES | FC(F)(F)c1ccc(cc1)N1CCN(CC1)C(=O)[C@@H](c1ccc(Cl)cc1)c1cccnc1 |r| |
Structure |
|