Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetIsoform Tau-F of Microtubule-associated protein tau
LigandBDBM32329
Substrate/Competitorn/a
Meas. Tech.Tau Protein Assay
pH7.4±n/a
IC50 2.8e+2± 4e+1 nM
Commentsextracted
Citation Schafer, KN; Cisek, K; Huseby, CJ; Chang, E; Kuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem288:32599-611 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Isoform Tau-F of Microtubule-associated protein tau
Name:Isoform Tau-F of Microtubule-associated protein tau
Synonyms:MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN
Type:Enzyme Catalytic Domain
Mol. Mass.:45857.42
Organism:Homo sapiens (Human)
Description:P10636-8
Residue:441
Sequence:
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPK
TPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAK
SRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHV
PGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNI
THVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMV
DSPQLATLADEVSASLAKQGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM32329
n/a
NameBDBM32329
Synonyms:(2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methyl-prop-2-enylidene]-1,3-benzothiazole;iodide | (2Z)-3-ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;iodide | Cyanines, 1 | MLS001018610 | SMR000354813 | cid_6364517
TypeSmall organic molecule
Emp. Form.C22H23N2S2
Mol. Mass.379.561
SMILESCCN1\C(Sc2ccccc12)=C\C(\C)=C\c1sc2ccccc2[n+]1CC
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: