Ki Summary

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Target

Isoform Tau-F of Microtubule-associated protein tau

Ligand

BDBM214727

Substrate/Competitor

n/a

Meas. Tech.

Tau Protein Assay

7.4±n/a

IC50

1.28e+3± 3.2e+2 nM

Comments

extracted

Citation

Schafer, KN; Cisek, K; Huseby, CJ; Chang, E; Kuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem288:32599-611 (2013) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Isoform Tau-F of Microtubule-associated protein tau

Name:

Isoform Tau-F of Microtubule-associated protein tau

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

45857.42

Organism:

Homo sapiens (Human)

Description:

P10636-8

Residue:

441

Sequence:

MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPK
TPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAK
SRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHV
PGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNI
THVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMV
DSPQLATLADEVSASLAKQGL

BDBM214727

n/a

Name

BDBM214727

Synonyms:

Azure B (11)

Type

Small organic molecule

Emp. Form.

C15H16N3S

Mol. Mass.

270.372

SMILES

CNc1ccc2nc3ccc(cc3sc2c1)=[N+](C)C |(-6.26,1.98,;-4.92,1.21,;-3.59,1.98,;-3.59,3.52,;-2.25,4.29,;-.92,3.52,;.41,4.29,;1.75,3.52,;3.08,4.29,;4.41,3.52,;4.41,1.98,;3.08,1.21,;1.75,1.98,;.41,1.21,;-.92,1.98,;-2.25,1.21,;5.75,1.21,;7.08,1.98,;5.75,-.33,)|

Structure