| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Tau-F of Microtubule-associated protein tau |
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| Ligand | BDBM214743 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Tau Protein Assay |
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| pH | 7.4±n/a |
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| IC50 | 6.5e+2±n/a nM |
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| Comments | extracted |
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| Citation |  Schafer, KN; Cisek, K; Huseby, CJ; Chang, E; Kuret, J Structural determinants of Tau aggregation inhibitor potency. J Biol Chem288:32599-611 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Tau-F of Microtubule-associated protein tau |
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| Name: | Isoform Tau-F of Microtubule-associated protein tau |
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| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein | Microtubule-associated protein Tau isoform 2N4R (Tau 2N4R) | Microtubule-associated protein tau (TAU)(2N4R) | TAU | TAU_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45857.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10636-8 |
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| Residue: | 441 |
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| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPK
TPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAK
SRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHV
PGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNI
THVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMV
DSPQLATLADEVSASLAKQGL
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| BDBM214743 |
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| n/a |
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| Name | BDBM214743 |
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| Synonyms: | Rhodanines, 31A |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11ClNO4S2 |
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| Mol. Mass. | 392.857 |
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| SMILES | [O-]C(=O)CCN1C(=S)S\C(=C/c2ccc(o2)-c2ccccc2Cl)C1=O |
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| Structure | 
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