| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 [H219A] |
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| Ligand | BDBM21278 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| pH | 7.4±n/a |
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| Kd | 2.5±0.6 nM |
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| Comments | extracted |
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| Citation |  Shim, JY; Ahn, KH; Kendall, DA Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gaiß¿: identification of key CB1 contacts with the C-terminal helix a5 of Gai. J Biol Chem288:32449-65 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 [H219A] |
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| Name: | Cannabinoid receptor 1 [H219A] |
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| Synonyms: | CNR | CNR1 | CNR1_HUMAN | Cannabinoid receptor 1 (CB1 H219A) |
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| Type: | Protein |
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| Mol. Mass.: | 52802.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human CB1 H219A mutant |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIARPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM21278 |
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| n/a |
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| Name | BDBM21278 |
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| Synonyms: | 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide | Acomplia | CHEMBL111 | CHEMBL558598 | RIMONABANT HYDROCHLORIDE | Rimonabant | SR 141716A | SR141716 | SR141716A | [3H]Rimonabant | [3H]SR141716A |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21Cl3N4O |
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| Mol. Mass. | 463.787 |
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| SMILES | Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1 |
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| Structure | 
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