| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50327809 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescent Based Assay |
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| pH | 7±n/a |
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| IC50 | 2.8±n/a nM |
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| Comments | extracted |
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| Citation |  Hammock, BD; Rose, T; Morisseau, C; Lee, KS Acyl piperidine inhibitors of soluble epoxide hydrolase US Patent US9296693 Publication Date 3/29/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Eph2 | Ephx2 | Epoxide hydratase | HYES_MOUSE | Soluble epoxide hydrolase (sEH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62512.06 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | P34914 |
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| Residue: | 554 |
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| Sequence: | MALRVAAFDLDGVLALPSIAGAFRRSEEALALPRDFLLGAYQTEFPEGPTEQLMKGKITF
SQWVPLMDESYRKSSKACGANLPENFSISQIFSQAMAARSINRPMLQAAIALKKKGFTTC
IVTNNWLDDGDKRDSLAQMMCELSQHFDFLIESCQVGMIKPEPQIYNFLLDTLKAKPNEV
VFLDDFGSNLKPARDMGMVTILVHNTASALRELEKVTGTQFPEAPLPVPCNPNDVSHGYV
TVKPGIRLHFVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSSSP
PEIEEYAMELLCKEMVTFLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPF
MPPDPDVSPMKVIRSIPVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRASDETGFIAVHK
ATEIGGILVNTPEDPNLSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSCKGLG
RKILVPALMVTAEKDIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQILIKW
LQTEVQNPSVTSKI
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| BDBM50327809 |
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| n/a |
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| Name | BDBM50327809 |
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| Synonyms: | 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea | CHEMBL1258904 | US10383835, Compound 1770 | US11123311, Compound 1770 | US9296693, 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H20F3N3O3 |
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| Mol. Mass. | 359.3435 |
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| SMILES | CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1 |
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| Structure | 
|
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