| Reaction Details |
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 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
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| Ligand | BDBM50092069 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.43±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 8±n/a nM |
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| Comments | extracted |
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| Citation |  Mereddy, VR; Drewes, LR; Alam, MA; Jonnalagadda, SK; Gurrapu, S Therapeutic compounds US Patent US9296728 Publication Date 3/29/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monocarboxylate transporter 1 |
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| Name: | Monocarboxylate transporter 1 |
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| Synonyms: | MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53245.17 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P53987 |
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| Residue: | 494 |
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| Sequence: | MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSW
ISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIG
GLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLI
LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQ
TVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAF
VDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAF
GWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACG
VILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPL
QNSSGDPAEEESPV
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|
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| BDBM50092069 |
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| n/a |
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| Name | BDBM50092069 |
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| Synonyms: | CHEMBL3582422 | US9296728, 20 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18N2O3 |
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| Mol. Mass. | 370.4006 |
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| SMILES | COc1cc(ccc1\C=C(/C#N)C(O)=O)N(c1ccccc1)c1ccccc1 |
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| Structure | 
|
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