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TargetUridine 5'-monophosphate synthase
LigandBDBM214781
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH8±n/a
Temperature298.15±n/a K
Ki 200±90 nM
Commentsextracted
Citation Zhang, YEvans, GBClinch, KCrump, DRHarris, LDFröhlich, RFTyler, PCHazleton, KZCassera, MBSchramm, VL Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem288:34746-54 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Uridine 5'-monophosphate synthase
Name:Uridine 5'-monophosphate synthase
Synonyms:Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN
Type:Enzyme
Mol. Mass.:52224.99
Organism:Homo sapiens (Human)
Description:P11172
Residue:480
Sequence:
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
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  Blast E-value cutoff:
BDBM214781
n/a
NameBDBM214781
Synonyms:OPRT inhibitor, 4
TypeSmall organic molecule
Emp. Form.C10H16BrN3O8P
Mol. Mass.417.127
SMILESOC1C(O)[C@H](Cn2cc(Br)c(=O)[nH]c2=O)[NH2+][C@@H]1COP(O)(O)=O |r|
Structure
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