| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K555C] |
|---|
| Ligand | BDBM214800 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | [3H]NMS/Carbachol Binding Assay |
|---|
| pH | 7.4±n/a |
|---|
| Kd | 0.553±0.017 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hu, J; Hu, K; Liu, T; Stern, MK; Mistry, R; Challiss, RA; Costanzi, S; Wess, J Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation. J Biol Chem288:34777-90 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K555C] |
|---|
| Name: | Muscarinic acetylcholine receptor M3 [1-273,470-589,N6Q,N15Q,N41Q,N48Q,N52Q,K555C] |
|---|
| Synonyms: | ACM3_RAT | Chrm-3 | Chrm3 | M3 muscarinic receptor (M3'(3C)-Xa K555C) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 46020.60 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Rat M3'(3C)-Xa with K555C mutation |
|---|
| Residue: | 405 |
|---|
| Sequence: | MTLHSQSTTSPLFPQISSSWVHSPSEAGLPLGTVTQLGSYQISQETGQFSSQDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEIEGRIEGRIEGRTRSQITKRKRMSLIK
EKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYA
LCNKTFRTTFCTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
|
|
|
|---|
| BDBM214800 |
|---|
| n/a |
|---|
| Name | BDBM214800 |
|---|
| Synonyms: | N-methylscopolamine (NMS) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H24NO4 |
|---|
| Mol. Mass. | 318.3869 |
|---|
| SMILES | C[N+]1(C)[C@H]2CC(C[C@@H]1[C@H]1O[C@@H]21)OC(=O)[C@H](CO)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
