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TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
LigandBDBM215311
Substrate/Competitorn/a
Meas. Tech.Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay)
pH7.4±n/a
Temperature298.15±n/a K
IC50 0.2±n/a nM
Commentsextracted
Citation Bartberger, MDGonzalez Buenrostro, ABeck, HPChen, XConnors, RVDeignan, JDuquette, JAEksterowicz, JFisher, BFox, BMFu, JFu, ZGonzalez Lopez De Turiso, FGribble, MWGustin, DJHeath, JAHuang, XJiao, XJohnson, MGKayser, FKopecky, DJLai, SLi, YLi, ZLiu, JLow, JDLucas, BSMa, ZMcGee, LRMcIntosh, JMcMinn, DLMedina, JCMihalic, JTOlson, SHRew, YRoveto, PMSun, DWang, XWang, YYan, XYu, MZhu, J Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer US Patent US9296736 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
Name:Cellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188]
Synonyms:MDM2 and p53 | mdm2
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:E3 ubiquitin-protein ligase Mdm2 [1-188]
Synonyms:E3 ubiquitin-protein ligase Mdm2 (aa 1-188) | MDM2 | MDM2_HUMAN
Type:n/a
Mol. Mass.:21319.18
Organism:Homo sapiens (Human)
Description:Q00987[1-188]
Residue:188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
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Component 2
Name:Cellular tumor antigen p53 [1-83]
Synonyms:P53 | P53_HUMAN | TP53 | Tumor suppressor p53
Type:Enzyme
Mol. Mass.:8975.74
Organism:Homo sapiens (Human)
Description:Residues 1-83
Residue:83
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPA
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BDBM215311
n/a
NameBDBM215311
Synonyms:US9296736, 273
TypeSmall organic molecule
Emp. Form.C32H33Cl2FN2O5S
Mol. Mass.647.584
SMILESC[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CN(c2ccccc2F)S(C)(=O)=O)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r|
Structure
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