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TargetMDM2 and p53
LigandBDBM50448955
Substrate/Competitorn/a
Meas. Tech.Homogenous Time-Resolved Fluorescence Assay (HTRF2 Assay)
pH7.4±n/a
Temperature298.15±n/a K
IC50 0.1±n/a nM
Commentsextracted
Citation Bartberger MDGonzalez Buenrostro ABeck HPChen XConnors RVDeignan JDuquette JAEksterowicz JFisher BFox BMFu JFu ZGonzalez Lopez De Turiso FGribble MWGustin DJHeath JAHuang XJiao XJohnson MGKayser FKopecky DJLai SLi YLi ZLiu JLow JDLucas BSMa ZMcGee LRMcIntosh JMcMinn DLMedina JCMihalic JTOlson SHRew YRoveto PMSun DWang XWang YYan XYu MZhu J Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer US Patent  US9296736 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
MDM2 and p53
Name:MDM2 and p53
Synonyms:n/a
Type:Enzyme
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:E3 ubiquitin-protein ligase Mdm2 (aa 1-188)
Type:n/a
Mol. Mass.:21319.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:188
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDS
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Component 2
Name:Tumor suppressor p53
Synonyms:n/a
Type:Enzyme
Mol. Mass.:8975.74
Organism:Homo sapiens (Human)
Description:Residues 1-83
Residue:83
Sequence:
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPA
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BDBM50448955
n/a
NameBDBM50448955
Synonyms:CHEMBL3125701 | US9296736, 354 | US9593129, Example 354
TypeSmall organic molecule
Emp. Form.C26H29Cl2NO5S
Mol. Mass.538.483
SMILESC[C@]1(CC(O)=O)C[C@@H]([C@H](N([C@H](CS(C)(=O)=O)C2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1 |r|
Structure
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