| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
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| Ligand | BDBM290235 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| pH | 7.5±n/a |
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| IC50 | 3.50±n/a nM |
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| Comments | extracted |
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| Citation |  Brameld, KA; Owens, T Benzimidazole derivatives as ITK inhibitors US Patent US9573958 Publication Date 2/21/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase ITK/TSK |
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| Name: | Tyrosine-protein kinase ITK/TSK |
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| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
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| Type: | Protein |
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| Mol. Mass.: | 71839.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08881 |
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| Residue: | 620 |
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| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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| BDBM290235 |
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| n/a |
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| Name | BDBM290235 |
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| Synonyms: | US9573958, Compound 62 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38F2N6O2S |
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| Mol. Mass. | 608.745 |
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| SMILES | C[C@H](NCc1ccc2n(C[C@H]3CCCN3C(=O)C(=CC3CC3)C#N)c(NC(=O)c3ccc(s3)C(F)F)nc2c1)C(C)(C)C |w:18.19| |
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| Structure | 
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