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TargetDiacylglycerol O-acyltransferase 2
LigandBDBM215446
Substrate/Competitorn/a
Meas. Tech.In Vitro DGAT2 Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 1.7±n/a nM
Commentsextracted
Citation Ahn KBoehm MCabral SCarpino PAFutatsugi KHepworth DKung DWOrr SWang J Diacylglycerol acyltransferase 2 inhibitors US Patent  US9296745 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 2
Name:Diacylglycerol O-acyltransferase 2
Synonyms:ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:Multi-pass membrane protein
Mol. Mass.:43848.90
Organism:Homo sapiens (Human)
Description:Q96PD7
Residue:388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM215446
n/a
NameBDBM215446
Synonyms:US9296745, 1
TypeSmall organic molecule
Emp. Form.C23H24F3N5O2
Mol. Mass.459.4642
SMILESFC(F)(F)Oc1cccc(c1)-c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1 |r|
Structure
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