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TargetDiacylglycerol O-acyltransferase 2
LigandBDBM215448
Substrate/Competitorn/a
Meas. Tech.In Vitro DGAT2 Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 4.82±n/a nM
Commentsextracted
Citation Ahn KBoehm MCabral SCarpino PAFutatsugi KHepworth DKung DWOrr SWang J Diacylglycerol acyltransferase 2 inhibitors US Patent  US9296745 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 2
Name:Diacylglycerol O-acyltransferase 2
Synonyms:ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:Multi-pass membrane protein
Mol. Mass.:43848.90
Organism:Homo sapiens (Human)
Description:Q96PD7
Residue:388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM215448
n/a
NameBDBM215448
Synonyms:US9296745, 3
TypeSmall organic molecule
Emp. Form.C25H27N7O
Mol. Mass.441.5282
SMILESO=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1cccc(c1)-n1cccn1)N1CCCC1 |r|
Structure
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