| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 2 |
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| Ligand | BDBM215538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DGAT2 Cell-Based Assay |
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| IC50 | 15.9±n/a nM |
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| Citation |  Ahn, K; Boehm, M; Cabral, S; Carpino, PA; Futatsugi, K; Hepworth, D; Kung, DW; Orr, S; Wang, J Diacylglycerol acyltransferase 2 inhibitors US Patent US9296745 Publication Date 3/29/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 2 |
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| Name: | Diacylglycerol O-acyltransferase 2 |
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| Synonyms: | ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 43848.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96PD7 |
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| Residue: | 388 |
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| Sequence: | MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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| BDBM215538 |
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| n/a |
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| Name | BDBM215538 |
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| Synonyms: | US9296745, 95 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N7O |
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| Mol. Mass. | 417.5068 |
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| SMILES | O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccnc(n1)C1CC1)N1CCCC1 |r| |
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| Structure | 
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