Reaction Details |
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Target | Myeloperoxidase |
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Ligand | BDBM217354 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Myeloperoxidase Assay |
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pH | 6.5±n/a |
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IC50 | 5.01± 0.02 nM |
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Comments | extracted |
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Citation | Forbes, LV; Sjögren, T; Auchère, F; Jenkins, DW; Thong, B; Laughton, D; Hemsley, P; Pairaudeau, G; Turner, R; Eriksson, H; Unitt, JF; Kettle, AJ Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. J Biol Chem288:36636-47 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Myeloperoxidase |
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Name: | Myeloperoxidase |
Synonyms: | 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 83888.32 |
Organism: | Homo sapiens (Human) |
Description: | P05164 |
Residue: | 745 |
Sequence: | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
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BDBM217354 |
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n/a |
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Name | BDBM217354 |
Synonyms: | 2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyrimidine-5-carbohydroxamic acid (HX1) |
Type | Small organic molecule |
Emp. Form. | C14H10F6N4O3 |
Mol. Mass. | 396.2446 |
SMILES | ONC(=O)c1cnc(NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[nH]c1=O |
Structure |
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