| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid peroxidase |
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| Ligand | BDBM217356 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LPO/TPO Selectivity Assay |
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| IC50 | 1.59e+3± 1e+1 nM |
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| Citation |  Forbes, LV; Sjögren, T; Auchère, F; Jenkins, DW; Thong, B; Laughton, D; Hemsley, P; Pairaudeau, G; Turner, R; Eriksson, H; Unitt, JF; Kettle, AJ Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. J Biol Chem288:36636-47 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid peroxidase |
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| Name: | Thyroid peroxidase |
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| Synonyms: | PERT_HUMAN | TPO | Thyroid peroxidase | Thyroid peroxidase (TPO) |
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| Type: | Enzyme |
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| Mol. Mass.: | 102965.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07202 |
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| Residue: | 933 |
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| Sequence: | MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
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| BDBM217356 |
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| n/a |
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| Name | BDBM217356 |
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| Synonyms: | 2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxamic acid (HX3) |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N4O3 |
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| Mol. Mass. | 260.2487 |
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| SMILES | ONC(=O)c1c[nH]c(NCc2ccccc2)nc1=O |
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| Structure | 
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