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TargetEstradiol-bound Estrogen receptor [255-595]
LigandBDBM217392
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Assay
pH7.4±n/a
Temperature298.15±n/a K
Kd 1.0e+3± 1e+2 nM
Commentsextracted
Citation Tressler, CMZondlo, NJ Perfluoro-tert-butyl Homoserine Is a Helix-Promoting, Highly Fluorinated, NMR-Sensitive Aliphatic Amino Acid: Detection of the Estrogen Receptor·Coactivator Protein-Protein Interaction by (19)F NMR. Biochemistry56:1062-1074 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Estradiol-bound Estrogen receptor [255-595]
Name:Estradiol-bound Estrogen receptor [255-595]
Synonyms:Estradiol-bound ERα LBD
Type:Protein
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Estrogen receptor [255-595]
Synonyms:ESR | ESR1 | ESR1_HUMAN | Estrogen receptor ligand binding domain (ERalpha LBD) | NR3A1
Type:Protein
Mol. Mass.:38412.26
Organism:Homo sapiens (Human)
Description:Human estrogen receptor ligand binding domain (255-595 aa)
Residue:341
Sequence:
IRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQ
MVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHD
QVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSR
FRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAG
LTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTS
RGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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Component 2
NameBDBM17292
Synonyms:(1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol | 17 beta-Estradiol | 17α-ethinylestradiol | 17beta-estradiol (E2) | CHEMBL135 | CS336 | ESTRADIOL | Estradiol-17 alpha | Ovocyclin | US9034854, E2 | US9040509, E2 | US9422324, E2 | US9561238, E2 | [2,4,6,7-3H]-17beta-estradiol | [2,4,6,7-3H]-E2 | [3H]-estradiol | [3H]]estradiol
TypeSteroid
Emp. Form.C18H24O2
Mol. Mass.272.382
SMILES[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H]
Structure
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BDBM217392
n/a
NameBDBM217392
Synonyms:CLTERHKILHRLLQE | NRBoxII
TypeSmall organic molecule
Emp. Form.C82H141N27O22S
Mol. Mass.1889.23
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure
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