Reaction Details | |||
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Target | Casein kinase II subunit beta | ||
Ligand | BDBM219758 | ||
Substrate/Competitor | BDBM220103 | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7±n/a | ||
IC50 | 679.1±n/a nM | ||
Comments | extracted | ||
Citation | Haddach, M; Tran, JA; Pierre, F; Regan, CF; Raffaele, N; Ravula, S; Ryckman, DM Pyrazolopyrimidines and related heterocycles as CK2 inhibitors US Patent US9303033 Publication Date 4/5/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Casein kinase II subunit beta | |||
Name: | Casein kinase II subunit beta | ||
Synonyms: | CK2N | CSK2B_HUMAN | CSNK2B | Casein kinase II subunit beta | Casein kinase II subunit beta (CK2 beta) | Casein kinase II subunit beta (CK2β) | G5A | Serine/threonine-protein kinase pim-2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 24937.13 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P67870 | ||
Residue: | 215 | ||
Sequence: |
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BDBM219758 | |||
BDBM220103 | |||
Name | BDBM219758 | ||
Synonyms: | US9303033, Q36, Table 41A, Compound 3 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H29N9O3 | ||
Mol. Mass. | 467.5242 | ||
SMILES | CN(C)C(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1 |r,wU:6.5,wD:9.12,(-9.59,3.35,;-8.26,4.12,;-8.26,5.66,;-6.92,3.35,;-5.59,4.12,;-6.92,1.81,;-5.59,1.04,;-4.26,1.81,;-2.92,1.04,;-2.92,-.5,;-4.26,-1.27,;-5.59,-.5,;-1.59,-1.27,;-.25,-.5,;-.25,1.04,;1.08,1.81,;1.08,3.35,;2.41,4.12,;3.95,4.12,;3.18,5.45,;2.41,1.04,;3.88,1.52,;4.78,.27,;3.88,-.98,;4.28,-2.46,;5.76,-2.86,;7.01,-1.96,;8.26,-2.86,;9.59,-2.09,;7.78,-4.33,;6.24,-4.33,;5.47,-5.66,;2.41,-.5,;1.08,-1.27,)| | ||
Structure |