Ki Summary

Reaction Details

Report a problem with these data

Target

Casein kinase II subunit beta

Ligand

BDBM218897

Substrate/Competitor

BDBM220103

Meas. Tech.

Inhibition Assay

7±n/a

IC50

476±n/a nM

Comments

extracted

Citation

Haddach, M; Tran, JA; Pierre, F; Regan, CF; Raffaele, N; Ravula, S; Ryckman, DM Pyrazolopyrimidines and related heterocycles as CK2 inhibitors US Patent US9303033 Publication Date 4/5/2016

More Info.:

Get all data from this article, Assay Method

Casein kinase II subunit beta

Name:

Casein kinase II subunit beta

Synonyms:

Type:

Enzyme

Mol. Mass.:

24937.13

Organism:

Homo sapiens (Human)

Description:

P67870

Residue:

215

Sequence:

MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR

BDBM218897

BDBM220103

Name

BDBM218897

Synonyms:

US9303033, E3, Table 10A, Compound 5 | US9303033, R36, Table 41A, Compound 4

Type

Small organic molecule

Emp. Form.

C20H26N8O4S

Mol. Mass.

474.537

SMILES

CS(=O)(=O)N[C@H]1CC[C@@H](CC1)Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1 |r,wU:5.4,wD:8.11,(-9.03,3.45,;-7.49,3.45,;-7.49,4.99,;-6.15,4.22,;-7.49,1.91,;-6.15,1.14,;-4.82,1.91,;-3.48,1.14,;-3.48,-.4,;-4.82,-1.17,;-6.15,-.4,;-2.15,-1.17,;-.82,-.4,;-.82,1.14,;.52,1.91,;.52,3.45,;1.85,4.22,;3.39,4.22,;2.62,5.56,;1.85,1.14,;3.31,1.62,;4.22,.37,;3.31,-.87,;3.71,-2.36,;5.2,-2.76,;6.45,-1.85,;7.69,-2.76,;9.03,-1.99,;7.22,-4.22,;5.68,-4.22,;4.91,-5.56,;1.85,-.4,;.52,-1.17,)|

Structure