| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM8892 |
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| Substrate/Competitor | BDBM8582 |
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| Meas. Tech. | Inhibition Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 1268±n/a nM |
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| Comments | extracted |
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| Citation |  Hartmann, R; Voets, M; Müller-Vieira, U Selective inhibitors of human corticosteroid synthases US Patent US9271963 Publication Date 3/1/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH |
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| Type: | Enzyme |
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| Mol. Mass.: | 57591.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15538 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS
PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
IKMVYSFILRPSMFPLLTFRAIN
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| BDBM8892 |
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| BDBM8582 |
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| Name | BDBM8892 |
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| Synonyms: | 3-(1-Methyl-3,4-dihydronaphthalen-2-yl)-pyridine | 3-(1-methyl-3,4-dihydronaphthalen-2-yl)pyridine | Dihydronaphthalene 6 | US9271963, 38 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N |
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| Mol. Mass. | 221.297 |
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| SMILES | CC1=C(CCc2ccccc12)c1cccnc1 |t:1| |
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| Structure | 
|
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