Reaction Details | |||
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Target | Tyrosine-protein kinase BTK | ||
Ligand | BDBM191629 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro HotSpot Kinase Assay | ||
IC50 | 3.48±n/a nM | ||
Citation | Honigberg, L; Verner, E; Buggy, J; Loury, D; Chen, W Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors US Patent US9278100 Publication Date 3/8/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase BTK | |||
Name: | Tyrosine-protein kinase BTK | ||
Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 76289.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q06187 | ||
Residue: | 659 | ||
Sequence: |
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BDBM191629 | |||
n/a | |||
Name | BDBM191629 | ||
Synonyms: | US9181263, 25 | US9278100, 25 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H35N7O3 | ||
Mol. Mass. | 553.6547 | ||
SMILES | Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CC[C@@H](CC1)NC(=O)\C=C\CN1CCOCC1 |r,wU:23.26,26.33,(-9.32,6.4,;-8.92,4.92,;-10.01,3.83,;-9.61,2.34,;-8.12,1.94,;-7.03,3.03,;-5.49,2.95,;-4.94,4.39,;-6.14,5.36,;-6.14,6.9,;-4.8,7.67,;-4.8,9.21,;-6.14,9.98,;-6.14,11.52,;-4.8,12.29,;-3.47,11.52,;-2.14,12.29,;-2.14,13.83,;-3.47,14.6,;-4.8,13.83,;-7.47,9.21,;-7.47,7.67,;-7.43,4.52,;-4.72,1.62,;-5.49,.28,;-4.72,-1.05,;-3.18,-1.05,;-2.41,.28,;-3.18,1.62,;-2.41,-2.39,;-.87,-2.39,;-.1,-3.72,;-.1,-1.05,;1.44,-1.05,;2.21,.28,;3.75,.28,;4.52,1.62,;6.06,1.62,;6.83,.28,;6.06,-1.05,;4.52,-1.05,)| | ||
Structure |