| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/Neuronal acetylcholine receptor subunit beta-2 |
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| Ligand | BDBM221048 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | [3H]Epibatidine Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 0.12±0.02 nM |
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| Comments | extracted |
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| Citation |  Carroll, FI; Ondachi, PW Nicotinic receptor compounds US Patent US9284322 Publication Date 3/15/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/Neuronal acetylcholine receptor subunit beta-2 |
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| Name: | Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/Neuronal acetylcholine receptor subunit beta-2 |
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| Synonyms: | Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2)/beta-2 | nAChR alpha4 beta2 subtype |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Isoform Alpha-4-2 of Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2) |
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| Synonyms: | ACHA4_RAT | Acra4 | Chrna4 | Neuronal acetylcholine receptor subunit alpha 4 subtype | Neuronal acetylcholine receptor subunit alpha-4 (Alpha-4-2) | Neuronal acetylcholine receptor subunit alpha-4 beta 2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 70323.63 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P09483-2 |
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| Residue: | 631 |
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| Sequence: | MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANI
SDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELI
WRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMK
FGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFI
IRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPS
PTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLF
MKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAV
ETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQ
EAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKE
PSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAM
VIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI
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| Component 2 |
| Name: | Neuronal acetylcholine receptor subunit beta-2 |
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| Synonyms: | ACHB2_RAT | Acrb2 | Chrnb2 | N-alpha 1 | Neuronal acetylcholine receptor non-alpha-1 chain |
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| Type: | Enzyme |
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| Mol. Mass.: | 56910.32 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P12390 |
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| Residue: | 500 |
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| Sequence: | MAGHSNSMALFSFSLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLM
VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYN
NADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRT
EIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINL
IIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYL
MFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRL
RLRRRQREREGAGALFFREGPAADPCTCFVNPASVQGLAGAFRAEPTAAGPGRSVGPCSC
GLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQPL
FQNYTATTFLHPDHSAPSSK
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| BDBM221048 |
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| n/a |
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| Name | BDBM221048 |
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| Synonyms: | US9284322, varenicline | US9303017, Varenicline |
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| Type | Small organic molecule |
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| Emp. Form. | C13H13N3 |
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| Mol. Mass. | 211.2624 |
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| SMILES | C1[C@H]2CNC[C@@H]1c1cc3nccnc3cc21 |
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| Structure | 
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