| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
|---|
| Ligand | BDBM220404 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PMSA Inhibition Assay |
|---|
| Ki | 1.34±0.64 nM |
|---|
| IC50 | 30.2±14.4 nM |
|---|
| Citation |  Spiegel, D; Murelli, R; Zhang, A Chimeric small molecules for the recruitment of antibodies to cancer cells US Patent US9296708 Publication Date 3/29/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Diacylglycerol O-acyltransferase 1 |
|---|
| Name: | Diacylglycerol O-acyltransferase 1 |
|---|
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55297.82 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75907 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
|
|
|
|---|
| BDBM220404 |
|---|
| n/a |
|---|
| Name | BDBM220404 |
|---|
| Synonyms: | US9296708, 10, MeO-P4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H41N5O12 |
|---|
| Mol. Mass. | 591.6086 |
|---|
| SMILES | COCCOCCOCCOCCOCc1cn(CCCC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)nn1 |
|---|
| Structure | 
|
|---|
Search and Browse
